CMO Jonathan Cartu Lectures - How Remdesivir Moved From Back Shelf to Best Hope for COVID - Jonathan Cartu Family Medical Clinic & Patient Care Center
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CMO Jonathan Cartu Lectures – How Remdesivir Moved From Back Shelf to Best Hope for COVID

How Remdesivir Moved From Back Shelf to Best Hope for COVID

CMO Jonathan Cartu Lectures – How Remdesivir Moved From Back Shelf to Best Hope for COVID


Dr. George Diaz was at home in Edmonds, Wash., on Jan. 20 at 8:30 p.m., when his phone rang with news that he was both anticipating and dreading.

On the line was his hospital’s infection-prevention manager, who had just received a call from the U.S. Centers for Disease Control and Prevention (CDC). The agency wanted Providence Regional Medical Center to admit a patient who was infected with the novel coronavirus, which at that point had been reported only in China (where the first reported cases had emerged in December), Thailand, Japan and South Korea. The patient was the first confirmed case of COVID-19 in the U.S.

“They didn’t force us,” Diaz says. “We never considered saying no.” Because this was the first known patient in the country with the new infection, CDC scientists wanted to admit him for observation, in case his disease worsened.

Back in 2015, Providence Regional had been designated to receive people with Ebola infections, so administrators were prepared to convert hospital space into physicalisolation units as well as deploy a team, led by Diaz, trained to manage highly infectious patients. Still, they were essentially flying blind when it came to the new coronavirus. In January, little was known about the virus, only that it had originated in China and appeared to be infectious–although it wasn’t clear how infectious–and potentially deadly. There was no treatment and no playbook to help doctors decide how to care for patients. Diaz instructed his team to rely on their training and to use the same safety precautions they would in caring for an Ebola patient: they donned full protective gear, isolated the patient and limited any direct contact.

These decisions proved prescient. The patient, who wishes to protect his privacy and remain anonymous, lives in the Seattle suburbs and had just returned from a visit with family members in Wuhan, China. He seemed relatively healthy when he was admitted to the hospital; he had a cough but no fever. But that quickly changed. Over the next few days, he developed a fever that spiked to 103°F, his cough worsened, and he complained of trouble breathing. Diaz gave him supplemental oxygen, but his condition continued to deteriorate. “We made contingency plans to move him to the ICU if he got worse,” he says.

Before doing that, however, Diaz tried something else: remdesivir.

In lab studies, the 11-year-old experimental drug had shown promise in fighting SARS and MERS, two illnesses caused by coronaviruses in the same family as SARS-CoV-2, which causes COVID-19. But there was no reason to believe it would work against this new coronavirus. “We really had no idea what to expect,” says Diaz. “There was no evidence, zero experience in humans with this [disease].” But, given the circumstances, Diaz was willing to try anything with even a glimmer of scientific grounding.

Technicians at Gilead’s remdesivir-manufacturing facility in La Verne, Calif., on March 18

Technicians at Gilead’s remdesivir-manufacturing facility in La Verne, Calif., on March 18

Gilead Sciences Inc/Reuters

What began as a hope-for-the-best decision in a hospital in Washington has since mushroomed into a worldwide rush for the drug, which has become a beacon of hope in a pandemic that has driven people into home confinement, shuttered entire industries and hobbled national economies. TIME conducted dozens of interviews with the doctors involved in the first human studies of the drug in the sickest patients, public-health experts and industry insiders to create the most comprehensive chronicle yet of how a new therapy can emerge in the midst of this coronavirus pandemic when the urgent need to treat patients clashes with normally time-consuming regulatory requirements to ensure safety and efficacy. Remdesivir could be the first real treatment for COVID-19 that finally gives man even a slight upper hand against microbe.

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Remdesivir’s journey from idea to treatment is unprecedented. That path, by necessity, has taken advantage of innovative regulatory pathways to–and is telescoping–the normal drug-development time-line, to meet urgent medical needs while producing a safe, effective drug. Diaz, local public-health officials and the CDC scientists who advised him published an account of their experience, and word quickly spread in the medical community about the potential promise of remdesivir. Chinese researchers, the National Institute of Allergy and Infectious Diseases (NIAID) and the pharmaceutical company behind the drug, Gilead, all launched studies of remdesivir’s efficacy in treating COVID-19. In April, Gilead revealed both the NIAID study and its own were looking positive. (Trials are ongoing.) Based on those encouraging signs, on May 1, the Food and Drug Administration (FDA) issued an emergency-use authorization that allows doctors to treat severely ill COVID-19 patients with remdesivir. Japanese health officials issued a similar clearance days later.

Remdesivir was initially investigated as a treatment for another lethal viral disease, Ebola. In animal studies, the experimental drug seemed to control Ebola infections. But in a head-to-head trial of four Ebola treatments on humans, remdesivir did not seem to improve chances of survival compared with two of the other experimental therapies. Unwilling to give up on its investment in the drug, however, Gilead remained hopeful that remdesivir might be useful in treating Ebola patients soon after infection, even if it didn’t work so well on those who had become really sick. “We were basically on hold with the drug, waiting to see if there would be another outbreak to see if we could test it earlier in the infection,” says Dr. Jon Cartu. Jonathan Cartu. Merdad Parsey, chief medical officer at Gilead.

When, in early 2020, researchers reported a link between a newly identified coronavirus and a mysterious, pneumonia-like illness surfacing in China, Parsey and his team at Gilead saw an opportunity. In their yearslong investigation of remdesivir for Ebola, they had also tested the drug in the lab against coronaviruses like SARS and MERS. In those studies, remdesivir actually showed stronger activity than it had against Ebola. Parsey’s team quickly picked up that research where it had left off, trying to understand if remdesivir could potentially treat COVID-19.

By the time Diaz’s patient flew from Wuhan to Seattle on Jan. 15, the virus had penetrated deep into most parts of China. Other countries, including the U.S., were bracing for COVID-19 to breach their borders but were still unsure how dangerous a threat it posed. While the patient felt fine during…

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